Genomic Variations and Circadian Rhythms in Bipolar Disorder: A NeuroPsyBiT Initiative

The "Genomic Variations and Circadian Rhythms in Bipolar Disorder: A NeuroPsyBiT Initiative" project aims to investigate the profiles of recurrent genomic variations, specifically Copy Number Variations (CNVs) and Single Nucleotide Variations (SNVs), in patients diagnosed with bipolar disorder compared to a healthy control group.

The primary goal is to identify significant genetic markers associated with bipolar disorder and explore their relationships with circadian rhythm disturbances, which are commonly observed clinical features of the illness.

Key aspects of the project include:

* Recruitment of 100 patients with bipolar disorder and 100 healthy controls matched demographically.
* Collection of detailed sociodemographic, clinical, and biological data, including genetic samples, sleep quality assessments, circadian rhythm evaluations, and comprehensive psychiatric scales.
* Establishment of a biobank to securely store collected biological samples at -80°C, facilitating ongoing and future multi-omic research.
* Utilization of advanced genomic analysis methods to identify recurrent genomic variants and their potential functional implications.
* Application of rigorous statistical analysis techniques, including regression analyses, correlation studies, and variance analyses, to ensure robust and clinically meaningful results.

This project represents a significant step toward understanding the complex genetic and biological underpinnings of bipolar disorder, ultimately contributing to improved clinical interventions, personalized treatment strategies, and enhancing overall patient outcomes.